Category Archives: Allergy/Asthma
This disease is widespread all over the world, hundreds of millions of people (5 - 10% of the world population) suffer from this disorder. Predisposition to asthma development of is higher at people who often suffered from colds, respiratory system inflammatory diseases, bronchitis, pneumonia.
- Asthma that occurs in case of increased sensitivity to infectious agents is called non-atopic.
- Atopic or allergic asthma develops on the background of increased sensitivity to allergens of different origin - plant pollen, chemicals in the air or entering body with drugs, dust, exhaust fumes. Atopic asthma is more common at people who suffer from eczema, conjunctivitis, neurodermatitis and other allergic reactions.
Causes and Risk FactorsAsthma usually manifests in early infancy, but with age it disappears or becomes milder with attacks appearing not more than once a week. Usually, cough attacks at asthma is combined with dyspnea, difficulties at exhalation. If asthma attacks are of allergic nature (atopic asthma), they are accompanied by symptoms that are characteristic for any allergy - urticaria fever, runny nose, swelling, watery eyes. For non-allergic asthma choking attacks are more common, they arise spontaneously, even without visible presence of allergens, bronchial tubes are sensitive to slightest irritation, such as temperature, humidity and atmospheric pressure changes. Parasitogenic infection can also cause asthma - if pathogenic agents are present in the body for a long time, immune system is reduced, sensitivity to even slight irritation increases. In conjunction with chronic bronchitis and other respiratory tract diseases, this leads to asthma attacks in response to household chemicals, drugs (e. g., aspirin), pollen. Roundworm larvae, penetrating lungs, cause coughing, provoke asthma development. Parasitic invasion may be unnoticeable to humans, as roundworms after coughing are usually reflexively swallowed. Other parasites that cause asthma: strongyloide, hookworm, toxocara.
- Rales at breathing caused by air passing through highly constricted bronchial passages;
- Painful cough at night and in the morning, worsening with air temperature decrease;
- Shortness of breath, inability to exhale, possible panic attacks. Patients with asthma use shoulders and neck muscles to facilitate exhalation;
- Increased chest – there is air in lungs that is impossible to completely exhale;
- At severe disease stage breathing is so difficult, that even wheezing of exhaled air is not audible, because its amount is too small.
Type of the disease at which complications are caused by hypersensitivity to aspirin, is called aspirin-induced asthma. Every decade a number of patients with severe chronic disease – bronchial asthma – is increasing. Asthma cause is increased upper respiratory tract sensitivity to external factors. Asthma triggering factors can be both viral infections and allergy to different substances. Canadian Health&Care Mall specialist decided to consider aspirin-induced asthma symptoms and treatment in details.
Definition and PathogenesisAspirin-induced asthma is a special type of asthma, at which one of the main precipitating factors is non-steroidal anti-inflammatory drugs. Aspirin-induced asthma is distinguished as a special type of asthma, similar to it in its symptoms. As with asthma, patients for many years suffer from dyspnea attacks and painful cough, sometimes developing into asthma attack, which limits their activities in life. Aspirin-induced asthma peculiarity is that its main reason is non-steroidal anti-inflammatory drugs. Many patients mistakenly believe that aspirin-induced asthma can only be caused by a drug that gave its name - aspirin. In fact, a large group of drugs, such as analgin, baralgin, diclofenac, ibuprofen, citramonum, has similar chemical structure. It is necessary to eliminate yellow dye – tartrazine, and pills in yellow coating, such as No-Spa. As a result of receiving these drugs more molecules that lead to bronchi narrowing are formed and substances, contributing their expansion, are insufficient. For this asthma type severe patients' condition is characteristic. At early disease stages there are detected immune and endocrine systems disorders. Patients complain of nasal congestion and profuse discharge that can last all year round. When taking aspirin, health condition is sharply deteriorating. Classic disease symptoms are: NSAID drugs intolerance, rhinitis and nasal polyps. The latter two symptoms may not appear at aspirin-induced asthma.
Diagnostics and TreatmentAspirin-induced asthma danger is that sometimes non-steroidal drugs are used to treat bronchial asthma. For example, to relieve asthma attack doctors may recommend baralgin, which includes anti-inflammatory drug - analgin. These drugs can cause a more severe asthma attack and lead to serious consequences, including death. Aspirin-induced asthma treatment does not differ from treatment of common type of this disease. Aspirin-induced asthma has one basic feature: patients are contraindicated NSAIDs. Caution should be taken when using paracetamol. Timely diagnostics of non-steroidal drugs intolerance is necessary. For diagnostics purposes, provocative tests with aspirin are commonly used. Doctors give patients small dosage of the drug and record external respiration indicators. To conduct this tests it is necessary to be very careful. Medical centers, where these tests are carried out, must necessarily have intensive care unit. There are three degrees of disease severity:
- mild: rare daytime and night-time attacks that can disappear on their own;
- moderately severe: nocturnal attacks appear more than twice a month;
- severe: frequent life-threatening attacks. Patients often require hospitalization.
- fluticasone propionate.
Aspirin-Induced Asthma at ChildrenBronchial asthma, combined with aspirin intolerance, often runs in families. You can observe families, in which asthma attacks as a result of receiving anti-inflammatory drugs appeared in four generations. Children in such families suffer from aspirin-induced asthma. Aspirin intolerance occurs in about 30% of children with asthma. Children may suffer from attacks of dry cough, dyspnea, especially at night and in the morning. In this disease treatment corticosteroids are often used. For proper treatment it is necessary to diagnose asthma type. Disease diagnostics at children has its difficulties. Usually provoking test method is too dangerous to apply to children. Another method is used – high-performance liquid chromatography, by which amount of leukotrienes released by leukocytes under indomethacin influence is determine. Test is performed using patient's venous blood. In any case, parents should watch what kind of reaction taken medications cause to note any deterioration. This will help doctor to make correct diagnosis. Dosage is selected depending on disease severity. The leading role in drug delivery is played by inhalation devices - nebulizers. They provide maximal drug penetration into respiratory tract. Ultrasonic nebulizers may be carried around.
Diet during DiseaseAt bronchial asthma special attention should be paid to patient’s diet. At severe disease course the following products should be entirely eliminated from the menu:
- canned foods;
- gastronomic products, that is, all kinds of sausages, ham or boiled pork;
- beer, liquor, wine, including champagne, coca-cola, coffee and tea (they contain large amounts of salicylates);
- products containing food dyes such as tartrazine (yellow dye) or red cochineal;
- red fruits and vegetables.