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In chronic disease, it is generally accepted that compliance is independent of age (excluding adolescence), sex, level of education, socioeconomic grouping and experience of symptoms and treatment side effects. Factors shown to be associated with nonadherence are a variety of psychopathologies (particularly depression ) and cognitive impairment. In the Lung Health Study, factors associated with long term metered dose inhaler adherence included being married, greater age, and having greater airway responsiveness, severe airflow obstruction and fewer hospitalizations . Medication regimens in asthma are particularly vulnerable to adherence problems because of the complexity of regimens with multiple medications, different methods of delivery and frequency of use, periods of symptom remission, long duration of use of medications, impact of disease on lifestyle, sometimes distressing side-effects, and the fact that the treatment regimen is preventive rather than curative . Lack of consistency in physician advice, heightened by medical disputes, contradictions and reverses, may also inadvertently contribute by reducing the patient’s willingness to accept medical recommendations. Nonadherence may also reflect dissatisfaction with care. For many, adherence represents a daily reminder of a condition that many would rather forget.