Pages
Health Care News
Categories
- Asthma education
- Autism
- Canadian Health&Care Mall
- Cardiac function
- Critical Care Units
- Follicle
- Health
- health care medical transport
- health care programs
- Health&Care Professionals
- Hemoptysis
- Hormone
- Isoforms
- Nitroglycerin Patches
- Profile of interleukin-10
- Progesterone
- Pulmonary Function
- Sertoli Cells
- Theophylline
- Tracheoesophageal Fistula
Category Archives: Isoforms
Distinct Expression Patterns of Different Subunit Isoforms: INTRODUCTION(3)
In addition, some of these subunits have more than one isoform encoded by different genes and with different tissue and subcellular expression patterns. Only one form has been identified for the A subunit of the human V-ATPase. This ubiquitous subunit has a nucleotide-binding site and is thought to be the catalytic subunit of the V-ATPase. Subunit B is present in two isoforms: the B1 isoform, originally called the kidney isoform of the 56-kDa subunit, and the B2 isoform, originally called the brain isoform of the 56-kDa subunit. Subunits C, G, and E are part of the peripheral stalk that connects the V1 and V0 domains of the V-ATPase.
(more…) Distinct Expression Patterns of Different Subunit Isoforms: INTRODUCTION(2)
Thus, in each individual cell type, the V-ATPase functions in a variety of distinct cellular processes.
The V-ATPase is a complex enzyme that is composed of many subunits and is divided into two distinct sectors. The V0 sector is responsible for proton translocation and is composed of the transmembrane subunits previously designated by the lowercase letters a, c, c', c'', and d. The V1 sector forms a large cytosolic domain composed of eight subunits, designated by the uppercase letters A-H in a stoichiometry of A3B3CDEFG2H and is anchored to the plasma membrane via its interaction with the V0 domain.
(more…)
Distinct Expression Patterns of Different Subunit Isoforms: INTRODUCTION(1)
The vacuolar-H+ATPase (V-ATPase) is a multisubunit enzyme that couples ATP hydrolysis to proton pumping across membranes. It is ubiquitously expressed in eukaryotic cells, where it participates in the acidification of highly differentiated organelles, including the Golgi apparatus, lysosomes, endo-somes, and secretory vesicles. In addition, the V-ATPase is also found at high density in the plasma membrane of specialized epithelial cells that are involved in active proton transport and pH regulation of extracellular compartments, such as narrow and clear cells in the epididymis and vas deferens, renal intercalated cells, osteoclasts, or some cell types in the inner ear, including interdental cells, which resemble renal intercalated cells.
(more…) 