Canadian Health&Care; Mall

Impotence is characterized by inability to achieve or maintain erection necessary for satisfactory sexual intercourse. In fight against male impotence it has developed a new drug – Canadian Uprima. The main active substance is apomorphine hydrochloride. Additive components are:

• magnesium stearate;
• microcrystalline cellulose;
• citric acid;
• hypromellose;
• ascorbic acid;
• disodium edetate;
• silicon dioxide;
• iron oxide red (E172);
• acesulfame potassium;
• mint and orange flavoring;
• mannitol.

Indications for Canadian Uprima Use

The main indications for Uprima use is increased activity of dopaminergic neurotransmitter system of brain to enhance sexual interest and acute sensations in people suffering from erectile dysfunction. Uprima is prescribed for ED treatment.

Released Form

Uprima is released in form of sublingual tablet of 2 mg (pentagonal lollipops) or 3mg (triangular candy) corresponding to the quantitative content of apomorphine hydrochloride. The red-brown pills are bi-engraving - the letter "a" on one side and the number 2 or 3 on the other.

Pharmacodynamics

The pharmacological action of Canadian Uprima online is directed to nuclei in the hypothalamus. This brain area is responsible for dopamine production, neurotransmitter system belongs to the group affecting ability to have fun. In turn, paraventricular nuclei in the hypothalamus is the area where focus sexual excitement aspects. Pharmacodynamic Canadian Uprima tablets properties are conditioned by apomorphine - main erection initiator sending proerectile impulse. Recovery of erectile function becomes possible thanks to central nervous system normalization that affects vascular response of penile cavernous tissue.

Pharmacokinetics

The half-life period of apomorphine is approximately 3 hours. Oral, intravenous and subcutaneous medication administration gives a maximum effect. Uprima of Canadian Pharmacy is available at Canadian Health&Care Mall healthcaremall4you.com at attractive price.

Canadian Uprima Pharmacokinetics

1. Absorption - through oral cavity mucosa, and after 10 minutes, apomorphine appears in the blood plasma (maximum concentration observed after 40-60 minutes);
2. Distribution - apomorphine 90% bound to plasma protein (albumin);
3. Metabolic break up - is accomplished mainly by correlation with glucuronic acid or sulphate. The second way is expansion through N-demethylation and creating norapomorphine, which is converted to glucuronide and sulfate;
4. Canadian Uprima excretion process - 2 mg sublingual administration determines 90% and 15% apomorphine presence approximately in urine and in feces respectively. Less than 2% of apomorphine detected in urine intactly. Faeces contain apomorphine norapomorphine and sulfates;
5. It should be noted that pharmacokinetics of Uprima - apomorphine has not been studied in women and persons under 18 years. Data on apomorphine pharmacokinetics relate to healthy men over 65 years.

Uprima Use during Pregnancy

It is banned to use Canadian Uprima online during pregnancy, by women, and by children.

Contraindications

Uprima contraindications apply to patients with severe angina, myocardial infarction, suffering from hypotension or cardiac insufficiency, as well as other diseases that limit sexual activity. The presence of individual intolerance of one of drug components will also be banned. People with liver disease of varying degrees of recommended dosage does not exceed 2 mg to strict medical supervision.

Uprima Side Effects

These medical observations for 4,000 patients of different ages with a diagnosis - “erectile dysfunction” pathogenic, organic, or mixed type who took 2-3ml of apomorphine revealed the following Uprima side effects:

• ability to develop vegetative syndrome manifested in spontaneous and brief drop in blood pressure, with consequent loss of consciousness (subject to the number of cases dosing less than 0.2%);
• deterioration of general condition, characterized by pain of various localization or headache;
• decrease in body's defenses and susceptibility to infection;
• vasodilation;
• nausea;
• drowsiness, loss of consciousness;
• short of breath feeling, rhinitis / pharyngitis exacerbation and cough;
• excessive sweating;
• changes in taste.

Admission for Canadian Uprima agreed with a specialist scheme shows good tolerability and documented cases of side effects. The drug was tested on patients with hepatic and renal insufficiency, diabetes mellitus, hypertension, spinal cord injuries and underwent prostatectomy. Side effects of these diseases did not differ from the frequency and intensity of other patients taking Canadian Uprima.

Dosing and Administration

The initial dosage of Uprima pills assigned to all patients is 2 mg. Number of tableted material was adjusted to a value sufficient for sexual intercourse. The value is adjusted individually and re-reception is performed with an 8-hour interval.

Dosing and Administration

• directly before sublingual administration, drink a little water, it will help medicine dissolve better;
• approximately 20 minutes before sexual intercourse, place the tablet under the tongue;
• complete dissolution of drug occurs, usually after 10 minutes. If after 20 minutes the tablet failed completely sucked, the rest should be swallowed; drug effectiveness increases sexual stimulation;
• sexual intercourse should start only when you are feeling ready for it.

Overdose

In the process of conducting clinical trials of Uprima tablets overdose any data were not revealed. Excess dosage of drug when administered sublingually often causes a gag reflex. Using the drug orally significantly reduces apomorphine effect as a result of metabolic breakdown.