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However, there was an increase in the proportions of primary and preantral follicles compared with untreated and recombinant mouse KITL-supplemented explants, although this difference was not statistically significant in all pairwise comparisons (Fig. 6). These data suggest that the inhibitory antibody possibly enhances receptor signaling. Effects of Culture and Recombinant Mouse KITL Treatment on Oocyte Growth in Rabbit Ovarian Cortical Explants We next measured and scored oocytes for developmental stage in order to determine the effects of culture and recombinant mouse KITL treatment on the growth of rabbit oocytes. The culture process itself was shown to increase the size of oocytes from follicles at the primordial and early primary stages. In untreated cultured tissue, the mean diameters of oocytes of primordial and early primary follicles were significantly (P < 0.05) larger than their preculture counterparts (Table 1). Conversely, the mean oocyte diameters of primary, growing primary, and preantral follicles were either unchanged or smaller (P < 0.05) than in preculture tissues (Table 1).